VSL#3 Modulates Colonic Macrophages, Inflammation, and Microflora in Acute Trinitrobenzene Sulfonic Acid Colitis
Scientific article “The Probiotic VSL#3 Modulates Colonic Macrophages, Inflammation, and Microflora in Acute Trinitrobenzene Sulfonic Acid Colitis” published by Journal of Histochemistry & Cytochemistry reports the analitic results of VSL#3’s effects on macrophages in acute trinitrobenzene sulfonic acid-induced colitis.
The probiotic mixture VSL#3 attenuates colitis in patients with Inflammatory Bowel Disease (IBD) and in animal models of this condition, authors explained, but the mechanisms involved are incompletely understood.
Rats were so randomized to normal, colitis, or colitis+VSL#3 groups. After sacrifice and evaluations, scientists concluded the probiotic VSL#3 reduces colitis severity, colonic macrophage infiltration, and serum cytokine levels, but does not dampen the pro-inflammatory phenotype of M1 macrophages.
Read the full abstract: https://journals.sagepub.com/doi/abs/10.1369/0022155417718542