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Benefits of multistrain bacteria formulations for health. VSL#3® showed efficacy. 

In the publication Benefits of multistrain bacteria formulations for health (Laterza et al., May 2018 pg. 542-544), the authors state that “The use of probiotics is very diffused in routine clinical practice, due to the good safety profile and the large availability of multiple products on the market. However, there still confusion in probiotic field regarding the appropriate use and definition of probiotics.”

Multistrain probiotics could be theoretically more effective due to the possible synergistic effect among different species and the high bacterial count

Among multistrain probiotic products, VSL#3® showed the highest number of double-blind, randomized, placebo-controlled clinical trials.

The main areas of study for multistrain probiotics are irritable bowel syndrome, antibiotic associated diarrhoea, H.pylori eradication and, for VSL#3®, also inflammatory bowel disease and hepatic encephalopaty.

VSL#3® showed efficacy in inducing remission in mild-to-moderate ulcerative colitis, in preventing hepatic encephalopathy, in reducing gastrointestinal complications in critically ill patients and in patients undergoing radiotherapy.